CBD, or cannabidiol, is a prominent compound of the cannabis plant, known as a phytocannabinoid.

Cannabis contains hundreds of different phytocannabinoids, including cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), as well as delta-9 tetrahydrocannabinol (THC) — the cannabis compound that is known for making its users feel “high”.

Understanding how phytocannabinoids work in the body requires a little bit of knowledge about the Endocannabinoid System, or ECS. The ECS consists of cannabinoid receptors, CB1 and CB2, that are found extensively throughout the brain and body. The external phytocannabinoids that are found in cannabis are specially designed to bind or interact with the internal cannabinoid receptors that exist within our body. When our CB receptors are activated, they produce neurotransmitters called endocannabinoids, known as anandamide and 2-Arachidonoylglycerol, or 2-AG. These endocannabinoids have a variety of responsibilities that span across the major body systems.

The ECS is a modulatory system, and it works by maintaining homeostatic balances between the major systems of the body.

CB receptors can be found everywhere: on neurons, white blood cells, and mitochondria, as well as concentrations in the spleen and digestive organs; there are also CB receptors located on skin cells. Endocannabinoids work differently than traditional neurotransmitters, partly because CB receptors are post-synaptic, and endocannabinoids are created on demand rather than being stored to await release.

Most phytocannabinoids are able bind with one or both of the cannabinoid receptors. For example, the binding of THC and CB1 receptors generates psychotropic effects in marijuana users; it also causes a tolerance to build over time as well withdrawal when its use is stopped. However, this is not true of CBD; its molecular structure prohibits it from binding with either CB1 or CB2 receptors — instead, it affects them indirectly.

CBD is able to inhibit the specific enzymes that dissolve anandamide from the bloodstream, thus enabling the endocannabinoid to continue performing its various responsibilities. CBD also mitigates the binding between THC and CB1 receptors, which means CBD will lessen the psychotropic effects of THC; this is why most commercial strains of marijuana are bred to have almost no CBD.

Scientists are continuing to study the numerous properties of CBD as well as other phytocannabinoids, and it is hopeful that their progress will lead to further understanding regarding the diverse characteristics of the cannabis plant.

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